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Argentina coach Santiago Phelan has moved his captain Felipe Contepomi to fly half for the second Test against England in Buenos Aires.
There are also five team changes as the Pumas look to draw the series following a crushing 32-3 defeat in the first test in Salta last weekend.
First Test halfbacks Martin Landajo and Benjamin Urdapilleta have been dropped from the squad with Nicolas Vergallo set to win his 35th capalongside Contepomi.
Gabriel Ascarate comes into the centre alongside the experienced Gonzalo Tiesi, who will also win a 35th cap, with Belisario Agulla replacing Matias Orlando on the right wing.
In the pack, loosehead Guillermo Roan replaces Pablo Henn and flanker Rodrigo Baez comes into the side for lock Esteban Lozada to play in the back row, Julio Farias Cabello moving to the second row.
"To play alongside Felipe [Contepomi] and Gonza [Tiesi] is really nice," said Ascarte. "I'll try to link with them, it's an extra incentive.
"We've been working a lot on winning the ball during the week. If we can get the ball it will be a different match. We have great players and a good team and I think that with attitude we can get a good result."
Halfbacks Tomas Cubelli and Benjamin Madero, who both appeareed for the CONSUR XV in England's opening tour match in Montevideo , have been rewarded with places on the bench for the match at the Velez Sarsfield stadium.
Argentina side to face England in Buenos Aires on Saturday, June 15: 15. Martin Bustos Moyano, 14. Belisario Agulla, 13. Gonzalo Tiesi, 12. Gabriel Ascarate, 11. Manuel Montero, 10. Felipe Contepomi (captain), 9. Nicolas Vergallo; 1. Guillermo Roan, 2. Martin Garcia Veiga, 3.Maximiliano Bustos, 4. Julio Farias Cabello, 5. Mariano Galarza, 6. Rodrigo Baez, 7. Benjamin Macome, 8. Tomas Leonardi.
Replacements: 16. Mauricio Guidone, 17. Pablo Henn, 18. Francisco Gomez Kodela, 19. Esteban Lozada, 20. Tomas De la Vega, 21. Tomas Cubelli, 22. Benjamin Madero, 23. Matias Orlando